Gender-bending is a famous way of updating a well-known individual and introducing a little twist. The MCU has achieved this technique several times before with characters just like the Ancient One, Ajak, and Makkari, so it would not be exactly groundbreaking for them to do it with Nicholas Scratch.
In the comics, Scratch is Agatha’s vengeful son. He normally adopts an adversarial position, performing as a villain to the Fantastic Four. Scratch is a effective magic user within the Marvel universe, and he makes perfect experience as the principle antagonist of Agatha’s display. Plaza could excel inside the role, bringing her trademark dry humor and injecting new lifestyles into the person.