In regards to Doctor Strange, a shift has taken place in the comics that has seen a brand-new figure take on the role of the Sorcerer Supreme. The wife of Stephen Strange, Clea, now protects Earth-616 after the death of her late husband.
Already an experienced Sorcerer Supreme for the Dark Dimension, Strange has been an intriguing narrative in seeing how Clea develops in the role. The MCU has just introduced the character, and thus it might be a brilliant change of pace for her to replace the Doctor in the coming years.
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